Systems

General Principles of Foundational Science (50%–55%)

• Gene expression: DNA structure, replication, exchange and epigenetics
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• Gene expression: transcription
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• Gene expression: translation
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• Structure and function of proteins and enzymes
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• Energy metabolism
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• Biology of cells
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• Cell biology of cancer
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• General principles of invasion and metastasis
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• Cell/tissue structure, regulation, and function
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• Human development and genetics
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• Genetic mechanism
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• Acute inflammatory responses
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• Pharmacodynamic and pharmacokinetic processes

Blood & Lymphoreticular System (1%–5%)

Nervous System & Special Senses (5%–10%)

Skin & Subcutaneous Tissue (1%–5%)

Musculoskeletal System (1%–5%)

Cardiovascular System (1%–5%)

Gastrointestinal System (1%–5%)

Renal & Urinary System (1%–5%)

Female Reproductive System & Breast (1%–5%)

Male Reproductive System (1%–5%)

Endocrine System (10%–15%)

Multisystem Processes & Disorders (20%–25%)

• Principles of nutrition Intracellular accumulations
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• Abnormal processes: nutrition
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• Toxins and environmental extremes
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• Enzymatic/metabolic disorders
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• Structural protein disorders
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• Intracellular/extracellular transport receptors 

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